Tau proteins are primarily located in axons and stabilize microtubules in neurons.  In certain neurodegenerative diseases, known as tauopathies, tau becomes detached from microtubules and forms insoluble aggregates in the brain, known as neurofibrillary tangles (NFTs). Because tau can no longer stabilize microtubules in this form, and tau oligomers and tangles can be neurotoxic, neurons cease to function and die.

StressMarq now offers two monomers and two PFFs that allow scientists to induce and study this effect in vitro.  This gives them the potential to investigate the mechanisms of tau aggregation, the effect of various tau species on neurons, and ability of certain drugs to inhibit tau aggregation.

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Products:

• Catalog No. SPR-327: Active Human Recombinant Tau441 (2N4R), P301S mutant Protein Monomer
• Catalog No. SPR-328: Active Human Recombinant Tau (K18), P301L mutant Protein Monomer
• Catalog No. SPR-329: Active Human Recombinant Tau441 (2N4R), P301S mutant Protein Pre-formed Fibrils
• Catalog No. SPR-330: Active Human Recombinant Tau (K18), P301L mutant Protein Pre-formed Fibrils

 

 

References

1. Ozcelic, S. et al. Mol Psychiatry. 2016, 21(12): 1790–1798.
2. alzforum.org/mutations/mutation-position-table/mapt-p301-mutations

 

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