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ConvertibleCAR-T, A Highly Adaptable
CAR-T Platform to Fight HIV |
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One potential approach to achieving a functional HIV cure
is to first reduce the size of the HIV reservoir and then engineer an immune
response that can effectively control the shrunken reservoir in the absence
of antiretroviral therapy. MicAbodies, comprised of full-length broadly
neutralizing HIV antibodies coupled to a mutated ligand, selectively engage a
mutant receptor that has been engineered as a chimeric antigen receptor (CAR)
and expressed on CD8 T cells (convertibleCAR-T cells). The
HIV-specific MicAbodies and the convertibleCAR-T cells can detect
and eliminate HIV infected cells. The modularity of the convertibleCAR-T
cell system allows multiplexing with several anti-HIV antibodies and yields
greater breadth and control, thus making this platform a promising tool for
attacking the latent HIV reservoir. |
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During
this webinar, we will discuss: |
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You
can add this webinar to you calendar now by clicking on the icon
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DBA-ITALIA Srl
Via Umbria 10
20090 Segrate (Milano)
Tel. +39 02-26922300
Fax +39 02-26926058
Fax +39 02-26923535