We’re thrilled to announce that Dr. Sigurdsson’s
distinguished research team conducted a cutting-edge
study on the efficacy and safety profile of sdAbs with
the help of ProSci, a leading provider of Custom Single
Domain (VHH) Antibody Services. The Sigurdsson Team
focused on immunoglobulin G (IgG) subclasses/subtypes
in targeting pathological tau protein in tauopathies.
The study utilized two single domain antibodies (sdAbs)
developed from a llama immunized with tau proteins.

Research Findings

Their research findings demonstrate that tau antibodies
with effector function are both safe and more effective
at clearing pathological tau than effectorless antibodies.
Furthermore, the study revealed that tau antibodies
have the potential to provide valuable insights into tau
pathogenesis, with some antibodies potentially
aggravating tau pathology (See publication).

These groundbreaking findings represent a significant
step forward in the understanding of tauopathies,
including Alzheimer’s disease, and hold enormous
promise for developing new treatments.

“The sdAbs that we made using the services of
ProSci continue to be important for our ongoing
studies to clarify the pathogenesis of various
neurodegenerative diseases and for developing
therapies and diagnostic markers for these
diseases.” -Dr. Einar Sigurdsson

We are excited to witness how researchers and
scientists are expanding the applications and utility of
single domain antibodies in their studies. The unique
characteristics of single domain antibodies open many
opportunities for researchers and scientists to develop
diagnostics and therapeutics.

Read the article here:
 Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity – eBioMedicine (thelancet.com)

Visit our website to learn more about how our CAS
services can advance your research endeavors.

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