| Target the Driver of Toxicity: New Alpha Synuclein Oligomer ELISA Kit |
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Achieve superior affinity for oligomers over fibrils and monomers with StressMarq’s SKT-143 |
| Alpha synuclein oligomers represent a soluble, neurotoxic form of the presynaptic protein and are increasingly recognized as early drivers of pathology in neurodegenerative disease. These oligomeric species disrupt synaptic vesicle trafficking and neurotransmission, impairing presynaptic function well before the formation of mature fibrillar aggregates. Localized effects extend to mitochondria, where oligomers induce oxidative stress, lysosomal dysfunction, and endoplasmic reticulum stress, contributing to neuronal vulnerability in Parkinson’s disease (PD) and related synucleinopathies. Their capacity to propagate in a prion like manner and initiate early synaptic and inflammatory disturbances underscores their importance in disease progression and positions them as high value targets for biomarker development and therapeutic intervention. StressMarq’s Alpha Synuclein Oligomer ELISA has demonstrated higher affinity to oligomers than to PFFs or monomers. |
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StressMarq has recently launched the new Alpha Sybuclein Oligomer ELISA Kit: ⇒ Superior Oligomer Selectivity: Specifically engineered to show significantly higher affinity for soluble oligomers compared to both monomers and pre-formed fibrils (PFFs) ⇒ Target the Early Mediators of Toxicity: Focus your research on the most neurotoxic species responsible for early-stage synaptic dysfunction and oxidative stress ⇒ Cross-Species Validation: Reliable performance in both human and mouse brain homogenates, bridging the gap between animal models and clinical research ⇒ High Sensitivity & Precision: Optimized for the detection of low-abundance oligomeric species, ensuring reproducible and accurate quantification ⇒ Streamlined Workflow: A ready-to-use 96-well colorimetric format that fits seamlessly into standard laboratory protocols ⇒ Validated by Experts: Developed by StressMarq, the world leader in specialized fibrillar and oligomeric protein constructs ⇒ Proven Research Tool: Ideal for longitudinal studies, drug screening, and monitoring the impact of anti-aggregation therapies |
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Quantification of mouse brain homogenate samples of unknown concentrations of alpha synuclein oligomers against a standard curve of human recombinant alpha synuclein oligomers using StressMarq’s Alpha Synuclein Oligomer ELISA kit (catalog# SKT-143). | |
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Robust detection of Human Recombinant Alpha Synuclein Oligomers (catalog# SPR-484) and limited cross-reactivity with Human Recombinant Alpha Synuclein Pre-Formed Fibrils and Monomers (catalog#s SPR-322 & SPR-321) using StressMarq’s Alpha Synuclein Oligomer ELISA kit (catalog# SKT-143). |
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Typical standard curve for StressMarq’s Alpha Synuclein Oligomer ELISA kit (catalog# SKT-143). |
| Product Name | Assay Range | Sensitivity | Sample Type | Reactivity | Size | Catalog# |
| Alpha Synuclein Oligomer ELISA Kit |
15.6 - 1,000 pg/mL | 10 pg/mL | Brain homogenate | Human, Mouse | 96 well | SKT-143 |
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