GelRed and GelGreen
 
The most safe and sensitive nucleic acid gel stains
 
GelRed® and GelGreen® are safe nucleic acid gel stains designed to replace highly toxic ethidium bromide (EtBr) and other so-called safe gel stains. These gel stains are non-toxic and non-mutagenic by virtue of being cell membrane impermeable. Ames tests have confirmed that GelRed® and GelGreen® are nonmutagenic at concentrations well above the concentrations used for gel staining. Furthermore, environmental safety tests showed that GelRed® and GelGreen® are non-toxic to aquatic life, permitting disposal down the drain or in regular trash.
 
 

 

Nucleic acid gel stain for polyacrylamide gels
 
The safety profile of the original GelRed® dye is in part due its large size, which makes the dye impermeable to cell membranes. However the large dye size reduces penetration of GelRed® into densely packed polyacrylamide gels. In designing PAGE GelRed® dye, Biotium used a novel approach to make the dye membrane impermeable without making the dye large. 
 


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