MedChemExpress-Master of Small Molecules (Inhibitors. Screening Libraries. Proteins)

From the early smallpox virus to SARS-CoV-2, every pandemic of viral infections poses a severe threat to human health[1][2]. Due to the virus’s mutability, infectivity, and drug resistance, vaccines and antiviral drugs targeting the virus need to be continuously improved[3]. So far, many viral diseases still lack effective therapeutic drugs, and natural products with diverse chemical structures and extensive pharmacological activities, making them essential source for discovery of new antiviral drugs[4].

Natural Product Antiviral Advantages

Natural products have more diverse ways of acting than synthetic compounds acting on a specific target during viral infection. Taking anti-SARS CoV-2 as an example, in addition to targeting some key proteins (3CLpro, ACE2, FURIN and RdRp), natural products also have immunomodulatory, anti-inflammatory and anti liver failure activities, which can regulate immune balance and reduce infection symptoms during the treatment of COVID-19[5].

Figure 1. Effect of natural products on SARS-CoV-2[5].

Application of Natural Antiviral Products

Many classic natural products have antiviral activity. For example, stilbene compounds (molecules with a styrene backbone and their polymers) represented by Resveratrol have extensive antiviral activity. Stilbene compounds can exist as monomers or polymers with a vast amount, providing a material basis for discovering new antiviral drugs[6].

MCE Provides a Variety of Natural Antiviral Products


Product Name




Specific SIRT1 activator, PXR inhibitor,
Nrf2 activator;
Other targets: mTOR, JAK, ß-amyloid,
Adenylyl cyclase, IKKß, DNA polymerase;
Anti-viral, anti-cancer, anti-inflammatory, antioxidant, cardioprotective activities.


SARS-COV-2 replication inhibitor;
Suppress ROS generation;
Anti-viral, anti-cancer, antioxidant, anti-inflammatory, and anti-diabetic effects.


Syk inhibitor;
Induces apoptosis and autophagy;
Anti-cancer, anti-inflammatory, and anti-viral activities.


Non-competitive tyrosinase inhibitor,
antioxidant, free radical scavenger;
Antiviral effcts, such as HSV-1, HSV-2, and varicella-zoster virus.



SARS-CoV-2 inhibitor, Cytochrome P450 inhibitor;
Antiviral, anticancer, anti-inflammatory, and analgesic effects.



Specific UGT1A9 probe substrate;
Inhibits influenza virus.

Benzene Quinones


Hsp90 inhibitor, H5N1 inhibitor;
Antiviral and anticancer activities.


Clemastanin B

Viral proliferation inhibitor;
Targets viral endocytosis, uncoating,
or ribonucleoprotein (RNP) export from the


[1] Biomed Res Int. 2021 Dec 8; 2021:7872406.
[2] Eur J Med Chem. 2020 Dec 1; 207: 112790.
[3] Environ Sci Pollut Res Int. 2022 Jun; 29(28): 42404-42432.
[4] Eur J Med Chem. 2023 Nov 15; 260: 115726.
[5] Phytother Res. 2022 Oct; 36(10): 3833-3858.